Dr Reddy's Labs is down 8.5 percent while Hero, HDFC Bank, Wipro and Lupin are major losers. Sun Pharma, Tata Motors, Infosys, L&T and HUL are top gainers.
The Indian rupee has opened marginally lower at 66.35 per dollar on Thursday against 66.32 a dollar in previous trading session.
Asian shares advanced in early trade on Thursday, while growing bets the European Central Bank was gearing up to deliver further stimulus steps kept the euro under pressure.
In fresh trouble for Dr. Reddy's Laboratories (DRL), a warning letter has been uploaded on the US Food and Drug Administration website with regards to DRL's plants it had inspected recently. The administrator has identified significant deviations from current good manufacturing practices (CGMP) at three of DRL's plants. The three plants that were inspected earlier by US FDA were Unit VI of Srikakulam Plant, Unit V at Telangana’s Miryalaguda Taluk Plant and Unit VII at the Duvvada Plant in Visakhapatnam. The American regulator says it has identified significant deviations from CGMP at all three plants. For the plant units in Srikakulam and Miryalaguda the deviations lay for manufacturing active pharma ingredients (API's), while for the Oncology Plant at Duvvada, the problem lay with finished pharmaceutical products.
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